Trifluoroacetic acid → HCID 18761271、化合物
反応式
C([O:5][C:6]([C:8]1[S:9][C:10]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:12]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:18]([O:17][C:15]([CH2:14][CH2:13][C:10]1[S:9][C:8]([C:6]([OH:7])=[O:5])=[CH:12][CH:11]=1)=[O:16])[CH3:19]参加物
4
実験手順
0.564 g (2 mmol) of 5-(2-ethoxycarbonyl-ethyl)-thiophene-2-carboxylic acid tert-butyl ester were dissolved in 10 ml of dichloromethane. 2.5 ml of trifluoroacetic acid were added dropwise with stirring at room temperature. Stirring was continued for 5 hours until the starting compound was no more detectable by thin layer chromatography (TLC). The solvents were evaporated in vacuo to give 0.45 g of a crystalline residue which was sufficiently pure for use in the subsequent step.
後処理
- stirringStirring
- customThe solvents were evaporated in vacuo
出典と根拠
- ORDレコード
- ord-fae22e0c113a4c668bc2b9998b8347de
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06660728B2
反応ノート
読み込み中…