Potassium Fluoride → 2-Cyano-3-fluoropyridine

HRID 431853

反応式

HRID 431853 の反応式
[C:1]([C:3]1[C:8](Cl)=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[F-:10].[K+]>CN1CCCC1=O.C(OCC)(=O)C>[C:1]([C:3]1[C:8]([F:10])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2]

参加物

5

反応物 2

HCID 522689Potassium FluorideHCID 8182583-Chloropyridine-2-carbonitrile

生成物 1

HCID 70604082-Cyano-3-fluoropyridine収率 50.1%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.

後処理

  1. temperatureheated
  2. temperatureat reflux for 18 hours
  3. temperatureAfter cooling
  4. extractionextracted with water and brine

出典と根拠

ORDレコード
ord-014da495d5b5402d8cbd5806a0c66b61
出典データセット
uspto-grants-2003_12
特許番号
US06660753B2

関連ノート

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