2,3-Difluorophenol → 3,4-Bis(4-methoxyphenyl)-6-(2,3-difluorophenoxy)pyridazine

HRID 432622

反応式

HRID 432622 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=1[OH:32]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:26]3[CH:27]=[CH:28][CH:29]=[C:30]([F:31])[C:25]=3[F:24])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 808792,3-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

生成物 1

HCID 102736293,4-Bis(4-methoxyphenyl)-6-(2,3-difluorophenoxy)pyridazine

実験手順

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (180 mg, 0.551 mmol) and 2,3-difluorophenol were reacted as starting materials at 150° C. for 19 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (203.3 mg, 90.0%). Melting point: 157.5-159.0° C. (chloroform-hexane).

後処理

  1. customat 150° C.
  2. customfor 19 hours

出典と根拠

ORDレコード
ord-b680130d5d8545f1a8890c75b8df9a63
出典データセット
uspto-grants-2003_12
特許番号
US06664256B1

関連ノート

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