Water → Butyl 4-nitrophenyl carbonate

HRID 43280

反応式

HRID 43280 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(N([CH2:16][CH3:17])CC)C.[C:18]([O:21][CH2:22][CH3:23])(=[O:20])C.O>O1CCCC1.ClC(OCCCC)=O>[C:18](=[O:20])([O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)[O:21][CH2:22][CH2:23][CH2:16][CH3:17]

参加物

7

反応物 4

HCID 962WaterHCID 9804-NitrophenolHCID 8471TriethylamineHCID 8857Ethyl Acetate

生成物 1

HCID 12867351Butyl 4-nitrophenyl carbonate

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 61140Butyl chloroformate溶媒

実験手順

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

後処理

  1. temperatureunder cooling on ice
  2. customThe organic layer was separated
  3. washwashed with a saturated sodium chloride aqueous solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customAfter removing the solvent
  6. customby evaporation under reduced pressure

出典と根拠

ORDレコード
ord-c9a5f1352fb34dfb8ee869cf977078d0
出典データセット
uspto-grants-2013_09
特許番号
US08536343B2

関連ノート

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