Methyl triflate → Methyl-tetrahydrothiopyran-4-one triflate
反応式
[S:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH3:8][O:9][S:10]([C:13]([F:16])([F:15])[F:14])(=[O:12])=[O:11]>ClCCl>[OH:12][S:10]([C:13]([F:16])([F:15])[F:14])(=[O:11])=[O:9].[CH3:8][CH:2]1[CH2:3][C:4](=[O:7])[CH2:5][CH2:6][S:1]1参加物
4
実験手順
2 mmol of tetrahydrothiopyran-4-one was dissolved in 5 ml of dichloromethane at 0° C., and about 2 mmol of methyltrifluoromethane sulfonate was slowly dripped to the mixture. The solvent was removed after about 30 minutes, and was then recrystallized with a mixture of ethyl acetate and hexane (1:2 by weight) to obtain a white solid product. The solid product was filtered and dried for 1 hour in an oven at 50° C. to obtain the following product:
後処理
- customThe solvent was removed after about 30 minutes
- customwas then recrystallized with a mixture of ethyl acetate and hexane (1:2 by weight)
- customto obtain a white solid product
- filtrationThe solid product was filtered
- customdried for 1 hour in an oven at 50° C.
- customto obtain the following product
出典と根拠
- ORDレコード
- ord-e251509fdc3047e78ec0d2f448c09308
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536347B2
反応ノート
読み込み中…