Methylamine → (Ferrocenylmethyl)methylamine

HRID 432969

反応式

HRID 432969 の反応式
[C-:1]1([CH:6]=O)[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH-:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:13].[CH3:14][NH2:15].[BH4-].[Na+]>C1COCC1.CO>[CH3:14][NH:15][CH2:6][C-:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH-:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:13]

参加物

6

反応物 3

HCID 6329MethylamineHCID 4311764Sodium borohydrideHCID 15184314Ferrocenecarboxyaldehyde

生成物 1

HCID 15912148(Ferrocenylmethyl)methylamine収率 86.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ferrocenecarboxaldehyde (700 mg, 3.27 mmol) and methylamine (2.0M in THF) (5.0 ml, 10.0 mmol) in THF (25 ml) and methanol (30 ml) was stirred at room temperature for 15 h under a nitrogen atmosphere. Sodium borohydride (371 mg, 9.81 mmol) was added to the solution and it was stirred at room temperature for 1 h. The solvent was removed out under reduced pressure and the residue dissolved in chloroform. The chloroform was washed with water, dried over magnesium sulphate. The solvent was removed under reduced pressure to yield a brown oil (647 mg, 86%).

後処理

  1. customThe solvent was removed out under reduced pressure
  2. dissolutionthe residue dissolved in chloroform
  3. washThe chloroform was washed with water
  4. dry with materialdried over magnesium sulphate
  5. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-b94a4a2f3e4448a68a13a414c8786a03
出典データセット
uspto-grants-2003_12
特許番号
US06664407B2

関連ノート

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