Water → 1-Iodo-4-methyl-4-nitro-pentane

HRID 432991ノート

反応式

HRID 432991 の反応式
CS(O[CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([N+:11]([O-:13])=[O:12])[CH3:10])(=O)=O.[I-:15].[Na+].O>CC(C)=O>[CH3:10][C:9]([N+:11]([O-:13])=[O:12])([CH3:14])[CH2:8][CH2:7][CH2:6][I:15]

参加物

5

反応物 3

HCID 962WaterHCID 5238Sodium IodideHCID 130471214-Methyl-4-nitropentyl methanesulfonate

生成物 1

HCID 99430631-Iodo-4-methyl-4-nitro-pentane収率 99.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4-Methyl-4-nitropentanol methanesulfonate (3.38 g, 15 mmol) was dissolved in acetone (50 ml) and sodium iodide (8.7 g, 58 mmol) was added. The mixture was stirred overnight. Water (20 ml) was added and acetone was evaporated by concentration under reduced pressure. The residue was extracted with ethyl acetate (50 ml). The extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate was evaporated by concentration under reduced pressure to give the objective compound (3.84 g, yield 99.6%).

後処理

  1. customacetone was evaporated by concentration under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate (50 ml)
  3. washThe extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate
  4. customwas evaporated by concentration under reduced pressure

出典と根拠

ORDレコード
ord-084abec90d204b638ecc24bdcab17c62
出典データセット
uspto-grants-2003_12
特許番号
US06664412B2

反応ノート

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