Sodium Hydroxide → 5-(4-Methyl-4-nitropentyl)hydantoin

HRID 433005ノート

反応式

HRID 433005 の反応式
[CH3:1][C:2]([N+:14]([O-:16])=[O:15])([CH3:13])[CH2:3][CH2:4][CH:5]=[C:6]1[NH:10][C:9](=[O:11])[NH:8][C:7]1=[O:12].[OH-].[Na+].[H][H]>[C].[Pd].CO>[CH3:13][C:2]([N+:14]([O-:16])=[O:15])([CH3:1])[CH2:3][CH2:4][CH2:5][CH:6]1[NH:10][C:9](=[O:11])[NH:8][C:7]1=[O:12]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 695837495-(4-Methyl-4-nitropentylidene)hydantoinHCID 178418361HCID 178418361、化合物

生成物 1

HCID 99427025-(4-Methyl-4-nitropentyl)hydantoin収率 72.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒2 回HCID 887Methanol溶媒

実験手順

Methanol (200 ml) was added to 5-(4-methyl-4-nitropentylidene)hydantoin (25.85 g, 114 mmol) and 27% aqueous sodium hydroxide solution was added to adjust the pH to 10 for dissolution. Palladium-carbon (1.1 g) and hydrogen were added for reduction. After the reaction, palladium-carbon was filtered off and methanol was evaporated by concentration under reduced pressure. Water (50 ml) was added and the pH was adjusted to 2 with concentrated hydrochloric acid. The precipitated crystals were separated and dried to give 5-(4-methyl-4-nitropentyl)hydantoin (19.02 g, 83 mmol, yield 72.9%).

後処理

  1. additionwas added
  2. dissolutionfor dissolution
  3. filtrationwas filtered off
  4. custommethanol was evaporated by concentration under reduced pressure
  5. additionWater (50 ml) was added
  6. customThe precipitated crystals were separated
  7. customdried

出典と根拠

ORDレコード
ord-7cc74fbf3b544f4984ad8eeef9695e61
出典データセット
uspto-grants-2003_12
特許番号
US06664412B2

反応ノート

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