Dimethylamine → Octanamide
反応式
C[NH:2]C.[C:4](Cl)(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>>[C:4]([NH2:2])(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]参加物
3
反応条件
- 温度
- 10 °C
実験手順
135.03 g of Dimethyl Amine solution is charged at room temperature and cooled to 10±2° C., then Octanoyl Chloride obtained in EXAMPLE 4 is charged at 8 to 12° C. over a period of 2 hours, and the reaction mixture is stirred at 10 to 15° C. for 30 minutes and then stirred at room temperature for 1 hour and the upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution) is added to the organic layer. This organic layer is washed and 9.94 g of Sodium Sulphate is added to the organic layer to take up water, and the mixture is filtered to obtain crude Octanamide.
後処理
- stirringstirred at room temperature for 1 hour
- customthe upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution)
- additionis added to the organic layer
- washThis organic layer is washed
- addition9.94 g of Sodium Sulphate is added to the organic layer
- filtrationthe mixture is filtered
出典と根拠
- ORDレコード
- ord-4a453be5931640edaf4b3ab0c2ecdb2b
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536355B2
反応ノート
読み込み中…