3-(4,4-Diethoxybutyl)-[1,3]oxazocan-2-one → 4-(2-Oxo-[1,3]oxazocan-3-yl)-butyraldehyde
反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][N:8]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][O:10][C:9]1=[O:16])C>O1CCCC1>[O:16]=[C:9]1[N:8]([CH2:7][CH2:6][CH2:5][CH:4]=[O:3])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][O:10]1参加物
3
実験手順
A mixture of 3-(4,4-diethoxybutyl)-[1,3]oxazocan-2-one (2 g, 7.3 mmole) and 1.5 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, and the filtrate was concentrated and dissolved in dichloromethane. The solution was dried with magnesium sulfate and concentrated to give 4-(2-oxo-[1,3]oxazocan-3-yl)-butyraldehyde (1.45 g) as a viscous oil which solidified.
後処理
- temperaturewas heated
- temperatureunder reflux for 24 hours
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
- dissolutiondissolved in dichloromethane
- dry with materialThe solution was dried with magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2e74f758152a44d9b38c4b3411cc8f19
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667301B2
反応ノート
読み込み中…