1-(3,3-Diethoxypropyl)tetrahydropyrimidin-2-one → 3-(2-Oxo-tetrahydropyrimidin-1-yl)propionaldehyde

HRID 433079ノート

反応式

HRID 433079 の反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][NH:9][C:8]1=[O:13])C>O1CCCC1>[O:13]=[C:8]1[NH:9][CH2:10][CH2:11][CH2:12][N:7]1[CH2:6][CH2:5][CH:4]=[O:3]

参加物

3

反応物 1

HCID 692247861-(3,3-Diethoxypropyl)tetrahydropyrimidin-2-one

生成物 1

HCID 840326263-(2-Oxo-tetrahydropyrimidin-1-yl)propionaldehyde収率 67.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1-(3,3-diethoxypropyl)tetrahydropyrimidin-2-one (1 g, 4.35 mmole), and 1.0 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, the filtrate was concentrated and the residue dissolved in dichloromethane (30 mL), dried with magnesium sulfate, and concentrated to give 3-(2-oxo-tetrahydropyrimidin-1-yl)-propionaldehyde (0.46 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated
  5. dissolutionthe residue dissolved in dichloromethane (30 mL)
  6. dry with materialdried with magnesium sulfate
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-85f339fd24924194a3511c162fda4d1d
出典データセット
uspto-grants-2003_12
特許番号
US06667301B2

反応ノート

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