Pyridine → N-(2-Chloro-4-fluorosulphonylphenyl)-2-acetoxy-2-methylpropanamide

HRID 433331ノート

反応式

HRID 433331 の反応式
[Cl:1][C:2]1[CH:8]=[C:7]([S:9]([F:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:13]([O:16][C:17]([CH3:22])([CH3:21])[C:18](Cl)=[O:19])(=[O:15])[CH3:14].N1C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[C:7]([S:9]([F:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:18](=[O:19])[C:17]([O:16][C:13](=[O:15])[CH3:14])([CH3:22])[CH3:21]

参加物

5

反応物 3

HCID 1049PyridineHCID 1234962-Acetoxyisobutyroyl chlorideHCID 2827514-Amino-3-chlorobenzenesulfonyl fluoride

生成物 1

HCID 18758703N-(2-Chloro-4-fluorosulphonylphenyl)-2-acetoxy-2-methylpropanamide収率 49.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-chloro-4-fluorosulphonylaniline (2.5 g, 12 mmol), 2-acetoxyisobutyryl chloride (2.35 g, 14 mmol) and pyridine (1.2 ml, 14.5 mmol), in DCM (50 ml) was stirred at ambient temperature for 18 h. The mixture was washed with water, dried and evaporated to dryness. The residue was purified by column chromatography using 25% EtOAc/isohexane and the oily product, the title compound (2.0 g, 5.9 mmol), solidified on standing. MS: 336.

後処理

  1. washThe mixture was washed with water
  2. customdried
  3. customevaporated to dryness
  4. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-4be0baf51a11426498c953b2f9f7af64
出典データセット
uspto-grants-2003_12
特許番号
US06667342B1

反応ノート

読み込み中…