Chlorotrimethylsilane → Methyl 2-(4-(bromomethyl)phenyl)acetate

HRID 43347

反応式

HRID 43347 の反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13][Si](Cl)(C)C>CO>[Br:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 45190564-(Bromomethyl)phenylacetic acid

生成物 1

HCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-(bromomethyl)phenylacetic acid (20 g, 87.3 mmol) in MeOH (200 ml) was added trimethylsilylchloride (2 ml) and the reaction stirred for 2 h. The solvent was removed in vacuo and the residue was twice re-dissolved in MeOH (200 ml) and re-concentrated to give the title compound (21.08 g). δH (CDCl3, 250 MHz) 7.36 (2H, d), 7.26 (2H, d), 4.49 (2H, s), 3.69 (3H, s), 3.62 (2H, s).

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was twice re-dissolved in MeOH (200 ml)
  3. concentrationre-concentrated

出典と根拠

ORDレコード
ord-b6f12120b68f4cc6a572fb91af9e6f91
出典データセット
uspto-grants-2013_09
特許番号
US08536182B2

関連ノート

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