2,4,6-Trimethylaniline → 6-(3,4-Dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenylamino)pyrimidine

HRID 4335

反応式

HRID 4335 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=2)[N:5]=[C:4]([CH3:18])[N:3]=1.[CH3:19][C:20]1[CH:26]=[C:25]([CH3:27])[CH:24]=[C:23]([CH3:28])[C:21]=1[NH2:22]>>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([C:6]2[N:5]=[C:4]([CH3:18])[N:3]=[C:2]([NH:22][C:21]3[C:23]([CH3:28])=[CH:24][C:25]([CH3:27])=[CH:26][C:20]=3[CH3:19])[CH:7]=2)[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]

参加物

3

反応物 2

HCID 69132,4,6-TrimethylanilineHCID 201522714-Chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

生成物 1

HCID 201522766-(3,4-Dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenylamino)pyrimidine

反応条件

温度
120 °C

実験手順

The mixture of 4-chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (2.0 g) and 2,4,6-trimethylaniline (5.3 ml) was stirred at 120° C. for an hour. After cooled, the mixture was triturated with ethyl acetate. The precipitates were collected, and dissolved in chloroform. The solution was washed with aqueous sodium bicarbonate solution, dried over magnesium sulfate, and evaporated to give 6-(3,4-dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenylamino)pyrimidine (2.39 g).

後処理

  1. temperatureAfter cooled
  2. customthe mixture was triturated with ethyl acetate
  3. customThe precipitates were collected
  4. dissolutiondissolved in chloroform
  5. washThe solution was washed with aqueous sodium bicarbonate solution
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-c718f36c041c43afbe95ad940fc057c9
出典データセット
uspto-grants-1988_02
特許番号
US04725600

関連ノート

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