2-Methylimidazole → HCID 9815053、化合物

反応式

[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[H-].[Na+].Cl[CH2:10][C:11]1[CH:12]=[N:13][N:14]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)[CH:15]=1>>[Cl:23][C:18]1[CH:17]=[C:16]([N:14]2[CH:15]=[C:11]([CH2:10][N:3]3[CH:4]=[CH:5][N:6]=[C:2]3[CH3:1])[CH:12]=[N:13]2)[CH:21]=[CH:20][C:19]=1[Cl:22]

参加物

反応物 3

HCID 127492-Methylimidazole

HCID 24758Sodium hydride

HCID 234450154-chloromethyl-1-(3,4-dichloro-phenyl)-1H-pyrazole

生成物 1

HCID 9815053HCID 9815053、化合物

実験手順

2-Methylimidazole was deprotonated with sodium hydride and then treated with 4-chloromethyl-1-(3,4-dichloro-phenyl)-1H-pyrazole. Extractive and chromatographic workup gave the title compound as a white crystalline solid. Mp. 176-177° C. (AcOEt), MS: m/e=307 (M+H+).

出典と根拠

ORDレコード: ord-a0ed47f7dfc7452ab2457fea6e96e6ce
出典データセット: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06667335B2

反応ノート

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