反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[I-:11].[Na+].[CH3:13]C(=O)CC>>[CH3:13][O:10][C:8](=[O:9])[C:6]1[CH:5]=[CH:4][N:3]=[C:2]([I:11])[CH:7]=1参加物
4
実験手順
A solution of 2-chloro-pyridine-4-carboxylic acid (5 g, 31.7 mmol) in butan-2-one (150 ml) was heated under reflux with sodium iodide for 6 h to afford the 2-iodo-isonicotinic acid (7.3 g, 92.4% yield) following extractive aqueous workup. This material was dissolved in THF (50 ml) and esterified with fresh etheral diazomethane solution (44 ml, 0.55 mol/l). After evaporation of the solvent and filtration through a pad of silica gel, [elution with CH2Cl2/(2M NH3 MeOH)=19:1] the title compound (2.3 g, 44%) was obtained as a dark yellow oil. MS: m/e=263.0 (M+).
出典と根拠
- ORDレコード
- ord-df735295b92940f2bc98b8d0c81edd2f
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667335B2
関連ノート
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