Acetic Acid → 1-(3-Difluoromethyl-4-fluoro-phenyl)-1H-imidazole-4-carboxylic Acid
反応式
[F:1][CH:2]([F:11])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[F:10])[NH2:6].[CH:12](OCC)(OCC)OCC.[N+:22]([CH2:25]C(OCC)=O)([O-])=O.[C:31]([OH:34])(=[O:33])[CH3:32]>[Fe]>[F:11][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([N:6]2[CH:12]=[C:32]([C:31]([OH:34])=[O:33])[N:22]=[CH:25]2)[CH:7]=[CH:8][C:9]=1[F:10]参加物
6
実験手順
Following the general method described in example 234, 3-difluoromethyl-4-fluoroaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. >247° C. dec. (H2O/dioxane), MS: m/e=255 (M-H−).
出典と根拠
- ORDレコード
- ord-eefacf6657dd4aaa964d55ca05586d76
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667335B2
反応ノート
読み込み中…