Acetic Acid → HCID 23445189、化合物

HRID 433628ノート

反応式

HRID 433628 の反応式
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].[CH:12](OCC)(OCC)OCC.[N+:22]([CH2:25]C(OCC)=O)([O-])=O.[C:31]([OH:34])(=[O:33])[CH3:32]>[Fe]>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([N:7]2[CH:12]=[C:32]([C:31]([OH:34])=[O:33])[N:22]=[CH:25]2)[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 176Acetic Acid2 回HCID 31214Ethyl orthoformate2 回HCID 69379Ethyl nitroacetateHCID 27741103-(Difluoromethoxy)aniline

生成物 1

HCID 23445189HCID 23445189、化合物

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

Following the general method described in example 234, 3-(difluoromethoxy)aniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. 190-191° C. (H2O/dioxane), MS: m/e=253 (M-H−).

出典と根拠

ORDレコード
ord-1c7438ed1d6a4ebcb9775e295e61a40f
出典データセット
uspto-grants-2003_12
特許番号
US06667335B2

反応ノート

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