Bromine → 2-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone

HRID 433919

反応式

HRID 433919 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[Br:21]Br>C(Cl)(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[Br:21][CH:9]([C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:17])=[O:18])=[CH:12][CH:11]=1)[C:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:20]

参加物

5

反応物 2

HCID 24408Bromine2 回HCID 112433011-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)ethanone

生成物 1

HCID 112340792-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone収率 75.4%

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒2 回HCID 6212Chloroform溶媒

実験手順

A mixture of 1-(4-fluorophenyl)-2-(4-methylsulfonyl phenyl)ethanone (14.6 g, 50 mmol) in 210 mL of chloroform and 826 mL of CCl4. A solution of 8.0 g (50 mmol) of bromine in CCl4 was added dropwise to the mixture. When the loss of the bromine colour was complete, the organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine. It was dried over anhydrous sodium sulfate. The drying agent was filtered, and the filtrate concentrated in vacuum to give 14.0 g (70%) of the desired product as a solid.

後処理

  1. washthe organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine
  2. dry with materialIt was dried over anhydrous sodium sulfate
  3. filtrationThe drying agent was filtered
  4. concentrationthe filtrate concentrated in vacuum

出典と根拠

ORDレコード
ord-84880694e21f4168b30407757433a720
出典データセット
uspto-grants-2003_12
特許番号
US06670365B1

関連ノート

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