Sodium Hydroxide → 3-(2,6-Difluorophenyl)-5-methylisoxazole-4-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:6]([C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[F:18])=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO>[C:3]([C:5]1[C:6]([C:11]2[C:12]([F:18])=[CH:13][CH:14]=[CH:15][C:16]=2[F:17])=[N:7][O:8][C:9]=1[CH3:10])([OH:4])=[O:2]参加物
4
実験手順
In a manner similar to that for preparation 16, 4-methoxycarbonyl-5-methyl-3-(2,6-difluorophenyl)isoxazole (0.244 g, 0.910 mmol), 5N NaOH (1 ml, 5.0 mmol), and methanol (10 ml) afforded 4-carboxy-5-methyl-3-(2,6-difluorophenyl)isoxazole (0.216 g, 93%) which was used without purification.
出典と根拠
- ORDレコード
- ord-3a3eede7160c4df49d472115bd8a1b3b
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06670373B1
反応ノート
読み込み中…