Hydrochloric Acid → HCID 59119734、化合物

L-Phenylalanine methyl ester hydrochloride (518 mg, 2.4 mmol) was suspended in tetrahydrofuran (12 mL), and at 0° C., N-methylmorpholine (242 mg, 2.4 mmol) was added, followed by stirring for 20 minutes. (S)-3-Benzoyl-4-methyl-2,5-oxazolidinedione (N-benzoyl-L-alanine-NCA (438 mg, 2 mmol) was added as crystals at 0° C. After the resulting mixture was stirred for 15 minutes, the mixture was allowed to rise in temperature to room temperature, at which the mixture was stirred for 15 minutes. The reaction mixture was poured into 1 N hydrochloric acid (25 mL), followed by extraction with ethyl acetate (25 mL). The organic layer was washed successively with a saturated aqueous solution of sodium hydrogencarbonate (25 mL) and a saturated aqueous solution of sodium chloride (25 mL), and was then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure. The resulting white solid was washed with hexane-ethyl acetate to afford the title compound (462 mg, 65%) as white crystals.

1. stirringAfter the resulting mixture was stirred for 15 minutes
2. customto rise in temperature to room temperature, at which
3. stirringwas stirred for 15 minutes
4. extractionfollowed by extraction with ethyl acetate (25 mL)
5. washThe organic layer was washed successively with a saturated aqueous solution of sodium hydrogencarbonate (25 mL)
6. dry with materiala saturated aqueous solution of sodium chloride (25 mL), and was then dried over anhydrous magnesium sulfate
7. concentrationThe organic layer was concentrated under reduced pressure
8. washThe resulting white solid was washed with hexane-ethyl acetate

ORDレコード

ord-2d928e96782b4168bd8fe66f854af487

出典データセット

uspto-grants-2003_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06670447B2