Benzyl Alcohol → Benzyl 4,4,4-trifluoroacetoacetate

HRID 434360ノート

反応式

HRID 434360 の反応式
[O:1]=[C:2]([C:9]([F:12])([F:11])[F:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O)[C:14]1[CH:19]=[CH:18]C=[CH:16][CH:15]=1>C(O)C>[O:1]=[C:2]([C:9]([F:10])([F:11])[F:12])[CH2:3][C:4]([O:6][CH2:7][C:8]1[CH:18]=[CH:19][CH:14]=[CH:15][CH:16]=1)=[O:5]

参加物

4

反応物 2

HCID 244Benzyl AlcoholHCID 67793Ethyl 4,4,4-trifluoroacetoacetate

生成物 1

HCID 13136519Benzyl 4,4,4-trifluoroacetoacetate収率 78%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-oxo-4,4,4-trifluorobutyrate (25 g, 0.136 mole) was heated between 100° and 180° C. under nitrogen with benzyl alcohol (14 ml, 0.136 mole) for 3 hours, the ethanol formed being distilled from the reaction mixture. The resulting pale yellow oil was distilled under vacuum to give a colourless oil (26.1 g, 78%), b.p. 81°-82° C. at 0.20 mm Hg.

後処理

  1. distillationbeing distilled from the reaction mixture
  2. distillationThe resulting pale yellow oil was distilled under vacuum

出典と根拠

ORDレコード
ord-c29cf148364040c688f61c65ca463628
出典データセット
uspto-grants-1983_08
特許番号
US04396626

反応ノート

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