Sulfuric Acid → 1-(4-Acetylphenyl) propan-2-one

HRID 434374ノート

反応式

HRID 434374 の反応式
[Cr](O)(O)(=O)=O.S(=O)(=O)(O)O.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[C:22]([C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH:32]([OH:34])[CH3:33])=[CH:27][CH:26]=1)(=[O:24])[CH3:23]>O.CCOCC>[C:22]([C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32](=[O:34])[CH3:33])=[CH:27][CH:26]=1)(=[O:24])[CH3:23]

参加物

7

反応物 4

HCID 1118Sulfuric AcidHCID 24425Chromic AcidHCID 25408Sodium DichromateHCID 225984461-(4-Acetylphenyl) propan-2-ol

生成物 1

HCID 122541111-(4-Acetylphenyl) propan-2-one

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 3283Diethyl Ether溶媒

実験手順

Chromic acid solution (11.5 ml, made by adding sulphuric acid [7.3 ml] to sodium dichromate [10.0 g] in water [30 ml] and making up to 50 ml with water) was added to a vigorously stirred solution of 1-(4-acetylphenyl) propan-2-ol (3.8 g) in ether (50 ml) keeping between 25°-30°. The mixture was stirred at ambient temperature for 2 hours, the organic phase was separated, washed with sodium bicarbonate solution and with saturated sodium chloride solution. The dried (MgSO4) solution was evaporated and distilled (2.5 g). b.p. 122°-128°/0.1 mm.

後処理

  1. customkeeping between 25°-30°
  2. customthe organic phase was separated
  3. washwashed with sodium bicarbonate solution and with saturated sodium chloride solution
  4. dry with materialThe dried (MgSO4) solution
  5. customwas evaporated
  6. distillationdistilled (2.5 g)

出典と根拠

ORDレコード
ord-a574549694e1498db4d2809191337e58
出典データセット
uspto-grants-1983_08
特許番号
US04396627

反応ノート

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