p-Fluorotoluene → 4-Fluorobenzyl bromide

HRID 434539

反応式

HRID 434539 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.C1C(=O)N([Br:16])C(=O)C1>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Br:16])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 9603p-FluorotolueneHCID 67184N-bromobutanimide

生成物 1

HCID 680214-Fluorobenzyl bromide収率 101.1%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide.

後処理

  1. temperaturethe mixture was refluxed for 2.0 hours
  2. customthe formed precipitate was removed by filtration
  3. washthe residual CCl4 solution was washed with dilute alkali
  4. dry with materialwith water, dried over Na2SO4
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-488f31c16d854192accd904c27116779
出典データセット
uspto-grants-1983_08
特許番号
US04397864

関連ノート

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