Aniline → Butanamide, 4-chloro-3-oxo-N-phenyl-

HRID 434559

反応式

HRID 434559 の反応式
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[Cl:8][CH2:7][C:2](=[O:5])[CH2:3][C:4]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]

参加物

5

反応物 2

HCID 6115AnilineHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

生成物 1

HCID 38215Butanamide, 4-chloro-3-oxo-N-phenyl-

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
0 °C

実験手順

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 150 parts of methylenechloride containing 4.2 parts of anhydrous sodium bicarbonate and the solution is cooled to 0° C. 4.7 Parts of aniline are then added over 30 minutes and the reaction mixture is finally stirred for 48 hours at room temperature. The solids are then filtered off and the filtrate evaporated. The residue is crystallised twice from chloroform to give γ-chloroacetoacetanilide, m.p. 142°-143° C.

後処理

  1. filtrationThe solids are then filtered off
  2. customthe filtrate evaporated
  3. customThe residue is crystallised twice from chloroform

出典と根拠

ORDレコード
ord-1de118cf597a444a877d081882727599
出典データセット
uspto-grants-1983_08
特許番号
US04398033

関連ノート

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