Sodium Hydroxide → HCID 178519985、化合物

HRID 43458

反応式

HRID 43458 の反応式
C[O:2][CH:3](OC)[C:4]1[NH:5][CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[F:12][C:9]([F:10])([F:11])[C:7]1[N:8]=[C:4]([CH:3]=[O:2])[NH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178499627HCID 178499627、化合物

生成物 1

HCID 178519985HCID 178519985、化合物収率 67%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
90 °C

実験手順

2 N sulfuric acid (20 ml) was added to 2-(dimethoxymethyl)-4-(trifluoromethyl)-1H-imidazole obtained in Example (33a) (720 mg, 3.43 mmol), and the mixture was stirred at 90° C. for one hour. The reaction solution was neutralized with a 1 N aqueous sodium hydroxide solution, followed by extraction with ethyl acetate. Then, the organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain 0.376 g of the title compound as a white solid (67%).

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. washThen, the organic layer was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f116ae624e084a38a2c47faa9fe69926
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

関連ノート

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