Sodium Hydroxide → HCID 178519985、化合物
反応式
C[O:2][CH:3](OC)[C:4]1[NH:5][CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[F:12][C:9]([F:10])([F:11])[C:7]1[N:8]=[C:4]([CH:3]=[O:2])[NH:5][CH:6]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
2 N sulfuric acid (20 ml) was added to 2-(dimethoxymethyl)-4-(trifluoromethyl)-1H-imidazole obtained in Example (33a) (720 mg, 3.43 mmol), and the mixture was stirred at 90° C. for one hour. The reaction solution was neutralized with a 1 N aqueous sodium hydroxide solution, followed by extraction with ethyl acetate. Then, the organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain 0.376 g of the title compound as a white solid (67%).
後処理
- extractionfollowed by extraction with ethyl acetate
- washThen, the organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-f116ae624e084a38a2c47faa9fe69926
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536197B2
反応ノート
読み込み中…