反応式
[CH3:1][O:2][C@H:3]1[C@@H:8]([NH:9][C:10](=[O:19])[O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7][CH2:6][NH:5][CH2:4]1.C(N(C(C)C)CC)(C)C.Br[C:30]1[S:31][C:32]([CH3:40])=[C:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[N:34]=1>>[CH2:12]([O:11][C:10]([NH:9][C@H:8]1[CH2:7][CH2:6][N:5]([C:30]2[S:31][C:32]([CH3:40])=[C:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[N:34]=2)[CH2:4][C@H:3]1[O:2][CH3:1])=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
4
反応物 3
生成物 1
実験手順
The same operation as in Example (38b) was performed using benzyl cis(±)-(3-methoxypiperidin-4-yl)-carbamate obtained in Example (40b) (0.2 g, 0.76 mmol), diisopropylethylamine (0.25 mL, 1.44 mmol) and ethyl 2-bromo-5-methyl-1,3-thiazole-4-carboxylate obtained in Example (40c) (0.2 g, 0.80 mmol), to obtain 157.6 mg of the title compound as a yellow oily substance (48%).
出典と根拠
- ORDレコード
- ord-470f9ebbcb234e25af132f96b316227b
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536197B2
関連ノート
読み込み中…