Sodium Hydroxide → 2-(2-Amino-4-thiazolyl)-2-ethoxyiminoacetic acid
反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH3:16])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+]>C(O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH3:16])[C:8]([OH:10])=[O:9])[N:6]=1参加物
4
実験手順
Ethyl 2-(2-amino-4-thiazolyl)-2-ethoxyiminoacetate (syn isomer, 5 g.) was added to a mixture of 1 N sodium hydroxide (45.9 ml.) and ethanol (30 ml.) and stirred at room temperature for 5 hours. After removing ethanol from the resultant solution under reduced pressure, the residue was dissolved in water (60 ml.) and adjusted to pH 2.0 with 10% hydrochloric acid. The solution was subjected to salting-out, and the precipitates were collected by filtration and dried to give 2-(2-amino-4-thiazolyl)-2-ethoxyiminoacetic acid (syn isomer, 2.9 g.).
後処理
- customAfter removing ethanol from the resultant solution under reduced pressure
- dissolutionthe residue was dissolved in water (60 ml.)
- filtrationthe precipitates were collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-33bafaf13c94419e93d5f4c90aec23f4
- 出典データセット
- uspto-grants-1983_08
- 特許番号
- US04399133
反応ノート
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