Hydrochloric Acid → HCID 178418513、化合物
反応式
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)=O.[S-:12][C:13]#[N:14].[K+].Cl.[OH2:17]>C(O)C>[OH:17][C:13]1[S:12][CH:3]=[C:4]([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=2)[N:14]=1参加物
6
実験手順
A mixture of α-bromo-4-acetylpyridine hydrobromide (140.0 g, 0.50 mol) and potassium thiocyanate (53.4 g, 0.55 mol) in absolute ethanol (1500 mL) was heated to reflux for two hours. To the resulting mixture was added concentrated hydrochloric acid (250 mL) and water (500 mL) and reflux continued for five hours. After cooling, the crystallized solid was collected by filtration and washed with ethanol. The resulting material was suspended in water and neutralized with aqueous sodium bicarbonate to obtain, after filtration and drying, 2-hydroxy-4-(4-pyridyl)thiazole 39.0 g, 44%). mp. 250° C.
後処理
- temperaturewas heated
- temperatureto reflux for two hours
- temperaturereflux
- temperatureAfter cooling
- filtrationthe crystallized solid was collected by filtration
- washwashed with ethanol
- customto obtain
- filtrationafter filtration
- customdrying
出典と根拠
- ORDレコード
- ord-765591272e9a4caba598731704b65f44
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04725606
反応ノート
読み込み中…