Hydrochloric Acid → HCID 178418513、化合物

HRID 4349

反応式

HRID 4349 の反応式
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)=O.[S-:12][C:13]#[N:14].[K+].Cl.[OH2:17]>C(O)C>[OH:17][C:13]1[S:12][CH:3]=[C:4]([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=2)[N:14]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 516872Potassium thiocyanateHCID 27762394-(Bromoacetyl)pyridine hydrobromide

生成物 1

HCID 178418513HCID 178418513、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of α-bromo-4-acetylpyridine hydrobromide (140.0 g, 0.50 mol) and potassium thiocyanate (53.4 g, 0.55 mol) in absolute ethanol (1500 mL) was heated to reflux for two hours. To the resulting mixture was added concentrated hydrochloric acid (250 mL) and water (500 mL) and reflux continued for five hours. After cooling, the crystallized solid was collected by filtration and washed with ethanol. The resulting material was suspended in water and neutralized with aqueous sodium bicarbonate to obtain, after filtration and drying, 2-hydroxy-4-(4-pyridyl)thiazole 39.0 g, 44%). mp. 250° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for two hours
  3. temperaturereflux
  4. temperatureAfter cooling
  5. filtrationthe crystallized solid was collected by filtration
  6. washwashed with ethanol
  7. customto obtain
  8. filtrationafter filtration
  9. customdrying

出典と根拠

ORDレコード
ord-765591272e9a4caba598731704b65f44
出典データセット
uspto-grants-1988_02
特許番号
US04725606

関連ノート

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