Hydrochloric Acid → 1-(3-Aminophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione

HRID 435047

反応式

HRID 435047 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[C:14](=[O:15])[CH2:13][C:12]([CH3:18])([CH2:16][CH3:17])[C:11]2=[O:19])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Cl.C(O)C>[Fe].O>[NH2:1][C:4]1[CH:5]=[C:6]([N:10]2[C:14](=[O:15])[CH2:13][C:12]([CH3:18])([CH2:16][CH3:17])[C:11]2=[O:19])[CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 131892323-Ethyl-3-methyl-1-(3-nitrophenyl)pyrrolidine-2,5-dione

生成物 1

HCID 131892171-(3-Aminophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

Seventy-four g. of N-m-nitrophenyl-2-methyl-2-ethylsuccinimide, as prepared in Example VI, was added portion wise to 60 g. of iron powder, 4 ml. of concentrated HCl, 200 ml. of ethanol and 160 ml. of water at reflux. When addition was complete and the temperature had fallen to 70° C., the mixture was treated with 4 g. of 50% NaOH and filtered immediately. The filtercake was washed with hot ethyl alcohol and the filtrate stripped under vacuum. The product which crystallized on removal of the ethyl alcohol weighed 49 g. when dry and had a m.p. of 100°-102° C. The product was identified as the title compound by analysis of infrared spectra.

後処理

  1. additionwas added portion wise to 60 g
  2. additionWhen addition
  3. customhad fallen to 70° C.
  4. additionthe mixture was treated with 4 g
  5. filtrationof 50% NaOH and filtered immediately
  6. washThe filtercake was washed with hot ethyl alcohol
  7. customThe product which crystallized on removal of the ethyl alcohol
  8. customwhen dry

出典と根拠

ORDレコード
ord-0da4dc040e1348cba3139d0453086179
出典データセット
uspto-grants-1983_08
特許番号
US04400202

関連ノート

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