Bromine → Methyl 4-bromo-3-oxopentanoate

HRID 43517

反応式

HRID 43517 の反応式
[O:1]=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[Br:10]Br>C(Cl)(Cl)Cl>[Br:10][CH:8]([CH3:9])[C:2](=[O:1])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

参加物

4

反応物 2

HCID 24408BromineHCID 121699Methyl 3-oxovalerate

生成物 1

HCID 9815681Methyl 4-bromo-3-oxopentanoate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Methyl 3-oxopentanoate (1 g, 7.68 mmol) was dissolved in chloroform (30 mL). Bromine (0.4 mL, 7.80 mmol) was added under ice-cooling and the mixture was stirred for 40 minutes. The reaction solution was washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

後処理

  1. temperaturecooling
  2. washThe reaction solution was washed with saturated aqueous sodium bicarbonate solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting compound was used for the next reaction without purification

出典と根拠

ORDレコード
ord-eeb1d3c862ba4424958c3286cfe142e9
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

関連ノート

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