反応式
[Cl:1][C:2]1[N:3]=[C:4]([C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][N:15]([C:18]3[S:19][C:20]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[C:21]([CH:23]=[O:24])[N:22]=3)[CH2:14][C@H:13]2[O:30][CH2:31][CH3:32])=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8].Cl([O-])=[O:34].[Na+].P([O-])(O)(O)=O.[Na+].CC(=CC)C>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][N:15]([C:18]3[S:19][C:20]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[C:21]([C:23]([OH:34])=[O:24])[N:22]=3)[CH2:14][C@H:13]2[O:30][CH2:31][CH3:32])=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8]参加物
5
反応物 4
生成物 1
実験手順
The same operation as in Example (33c) was performed using ethyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)-4-formyl-1,3-thiazole-5-carboxylate obtained in Example (68b) (about 0.63 mmol), sodium chlorite (113 mg, 1.25 mmol), sodium dihydrogenphosphate (320 mg, 2.05 mmol) and 2-methyl-2-butene (0.33 mL, 3.12 mmol), to obtain 312.7 mg of the title compound as a white solid (99%).
出典と根拠
- ORDレコード
- ord-6c6ef6ad472142c4bf230d3791b6bc15
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536197B2
関連ノート
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