Salicylaldehyde → 2-Phenylglycine

HRID 435464

反応式

HRID 435464 の反応式
[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.C(=O)[C:13]1[C:14](=[CH:16][CH:17]=[CH:18][CH:19]=1)[OH:15]>C(O)(=O)C>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:6]=1.[CH:17]1[C:18]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:19][CH:13]=[C:14]([OH:15])[CH:16]=1

参加物

5

反応物 2

HCID 6998SalicylaldehydeHCID 99291L-Phenylglycine

生成物 2

HCID 38662-PhenylglycineHCID 921434-Hydroxyphenylglycine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

6 g of L-phenylglycine or L-p-hydroxyphenylglycine were suspended in a mixture of 20 ml of 95% acetic acid and 0.2 ml (0.05 mole per mole of the L-amino acid used) of salicylaldehyde. The suspension was stirred at 100° C. for 2 hours. After the reaction, the mixture was cooled to room temperature, and the crystalline precipitates were collected by filtration and then washed with methanol. DL-phenylglycine or DL-p-hydroxyphenylglycine was thereby obtained. The results are shown in Table 17.

後処理

  1. customAfter the reaction
  2. temperaturethe mixture was cooled to room temperature
  3. customthe crystalline precipitates
  4. filtrationwere collected by filtration
  5. washwashed with methanol

出典と根拠

ORDレコード
ord-f17dfdb554054d039e49e8fe4c287923
出典データセット
uspto-grants-1983_08
特許番号
US04401820

関連ノート

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