Dicyclohexylcarbodiimide → Thyroxine

HRID 435514

反応式

HRID 435514 の反応式
C(O[NH:6][C@H:7]([C:27]([OH:29])=[O:28])[CH2:8][C:9]1[CH:16]=[C:14]([I:15])[C:13]([O:17][C:18]2[CH:25]=[C:23]([I:24])[C:22]([OH:26])=[C:20]([I:21])[CH:19]=2)=[C:11]([I:12])[CH:10]=1)(C)(C)C.ON1C(=O)CCC1=O.C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C=O>[NH2:6][C@H:7]([C:27]([OH:29])=[O:28])[CH2:8][C:9]1[CH:10]=[C:11]([I:12])[C:13]([O:17][C:18]2[CH:19]=[C:20]([I:21])[C:22]([OH:26])=[C:23]([I:24])[CH:25]=2)=[C:14]([I:15])[CH:16]=1

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 54358334HCID 54358334、化合物

生成物 1

HCID 5819Thyroxine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1.23 g (1.4 mmoles) of N-(tert-butoxy)-L-thyroxine and 0.16 g (1.4 mmoles) of N-hydroxysuccinimide are dissolved in 20 mL dimethylformamide. 0.31 g (1.5 mmoles) of dicyclohexyl carbodiimide is added to the solution which is then stirred at room temperature for 18 h. The urea precipitated during the reaction is removed by filtration and the filtrate, containing the active ester, is stored at -20° C.

後処理

  1. customThe urea precipitated during the reaction
  2. customis removed by filtration
  3. additionthe filtrate, containing the active ester
  4. customis stored at -20° C.

出典と根拠

ORDレコード
ord-766db094727d4f78be203c00f89a3ea5
出典データセット
uspto-grants-1983_08
特許番号
US04401765

関連ノート

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