Thionyl Chloride → 3-Methyl-6-(phenylthio)-benzyl chloride

HRID 435665ノート

反応式

HRID 435665 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:7]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:9]=1)[CH2:5]O.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[C:4]([C:7]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:9]=1)[CH2:5][Cl:19]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 12539099HCID 12539099、化合物

生成物 1

HCID 125391003-Methyl-6-(phenylthio)-benzyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

570.7 g of 3-methyl-6-(phenylthio)-benzyl alcohol are dissolved in 1.5 litres of benzene and heated under reflux. There are added dropwise thereto within 45 minutes 352 ml of thionyl chloride and the mixture is boiled for a further 90 minutes. Then the mixture is concentrated under reduced pressure and there is obtained 3-methyl-6-(phenylthio)-benzyl chloride as a red-brown oil.

後処理

  1. temperatureheated
  2. temperatureunder reflux
  3. additionThere are added dropwise
  4. concentrationThen the mixture is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5c9ac29b07614bd8afa424a4ace031fa
出典データセット
uspto-grants-1977_02
特許番号
US04006144

反応ノート

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