Water → 2-Azido-1-oxo-1lambda~5~-quinoline

HRID 435740ノート

反応式

HRID 435740 の反応式
Cl.Cl[C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:13].[N-:14]=[N+:15]=[N-:16].[Na+].O>CC(C)=O>[N:14]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[O-:13])=[N+:15]=[N-:16]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 21481204136545-12-5

生成物 1

HCID 126998242-Azido-1-oxo-1lambda~5~-quinoline

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In this example, 2.00 grams (0.009 mol) of 2-chloroquinoline N-oxide hydrochloride and 2.00 grams (0.031 mol) of sodium azide were added to and dissolved in 50 ml. of water and 100 ml. of acetone and the resulting solution stirred for 72 hours at 25° C. A solid separated and was collected by filtration. Recrystallization of this solid from benzene gave 2-azidoquinoline N-oxide in a yield of 1.01 grams or 58% of theory having a melting point of 103.5° C. to 104.5° C. with decomposition.

後処理

  1. dissolutiondissolved in 50 ml
  2. customA solid separated
  3. filtrationwas collected by filtration
  4. customRecrystallization of this solid from benzene

出典と根拠

ORDレコード
ord-d2329f2964394517995e3d7e4c5df4d0
出典データセット
uspto-grants-1977_02
特許番号
US04006160

反応ノート

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