Formaldehyde → 2-(hydroxymethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
反応式
[CH:1]1[CH:2]=[C:3]2[C:8]3=[C:9]([C:11]([NH:13][C:14](=[O:15])[C:7]3=[CH:6][CH:5]=[CH:4]2)=[O:12])[CH:10]=1.[CH2:16]=[O:17]>CN(C)C=O>[OH:17][CH2:16][N:13]1[C:14](=[O:15])[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]3[C:8]=2[C:9](=[CH:10][CH:1]=[CH:2]3)[C:11]1=[O:12]参加物
4
実験手順
30 g. (0.15 mole) of 1,8-naphthalimide and 12.5 ml. of 37% aqueous formaldehyde (0.17 mole) are combined in 100 ml. of dimethylformamide and heated on a hot plate (90°-110°) until all the materials dissolve. The solution is then allowed to stand overnight at 25°. The resulting precipitate is filtered off, washed with water and recrystallized from dioxane. This material is dried overnight at 25° (0.1 mm.) to yield 26.4 g. of the titled compound which has an indistinct melting point.
後処理
- dissolutiondissolve
- filtrationThe resulting precipitate is filtered off
- washwashed with water
- customrecrystallized from dioxane
- customThis material is dried overnight at 25° (0.1 mm.)
- customto yield 26.4 g
出典と根拠
- ORDレコード
- ord-3eab9337358e44f183a0432cc8c51e09
- 出典データセット
- uspto-grants-1977_02
- 特許番号
- US04006238
反応ノート
読み込み中…