Formaldehyde → 2-(hydroxymethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

HRID 435811

反応式

HRID 435811 の反応式
[CH:1]1[CH:2]=[C:3]2[C:8]3=[C:9]([C:11]([NH:13][C:14](=[O:15])[C:7]3=[CH:6][CH:5]=[CH:4]2)=[O:12])[CH:10]=1.[CH2:16]=[O:17]>CN(C)C=O>[OH:17][CH2:16][N:13]1[C:14](=[O:15])[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]3[C:8]=2[C:9](=[CH:10][CH:1]=[CH:2]3)[C:11]1=[O:12]

参加物

4

反応物 2

HCID 712FormaldehydeHCID 66491Naphthalimide

生成物 1

HCID 114135142-(hydroxymethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

30 g. (0.15 mole) of 1,8-naphthalimide and 12.5 ml. of 37% aqueous formaldehyde (0.17 mole) are combined in 100 ml. of dimethylformamide and heated on a hot plate (90°-110°) until all the materials dissolve. The solution is then allowed to stand overnight at 25°. The resulting precipitate is filtered off, washed with water and recrystallized from dioxane. This material is dried overnight at 25° (0.1 mm.) to yield 26.4 g. of the titled compound which has an indistinct melting point.

後処理

  1. dissolutiondissolve
  2. filtrationThe resulting precipitate is filtered off
  3. washwashed with water
  4. customrecrystallized from dioxane
  5. customThis material is dried overnight at 25° (0.1 mm.)
  6. customto yield 26.4 g

出典と根拠

ORDレコード
ord-3eab9337358e44f183a0432cc8c51e09
出典データセット
uspto-grants-1977_02
特許番号
US04006238

関連ノート

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