Formic Acid → N-(3-(dimethylamino)propyl)formamide

HRID 435923

反応式

HRID 435923 の反応式
[CH:1]([OH:3])=O.[CH3:4][N:5]([CH2:7][CH2:8][CH2:9][NH2:10])[CH3:6].C1(C)C=CC=CC=1>O>[CH3:4][N:5]([CH3:6])[CH2:7][CH2:8][CH2:9][NH:10][CH:1]=[O:3]

参加物

5

反応物 3

HCID 284Formic AcidHCID 1140TolueneHCID 7993N,N-Dimethyl-1,3-propanediamine

生成物 1

HCID 80020N-(3-(dimethylamino)propyl)formamide収率 59%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Formic acid (23 g., 0.5 mole), dimethylaminopropylamine (51 g., 0.5 mole) and toluene (50 ml) were azeotroped together with continual removal of water using a Dean and Stark separator until no more water was formed. Toluene was distilled off and the pale yellow residue distilled in vacuo. The colourless liquid product of low smell (N-(3-dimethylaminopropyl)formamide) was obtained in a yield of 59% of theory, b.p. 140° C/15 mm Hg.

後処理

  1. customwas formed
  2. distillationToluene was distilled off
  3. distillationthe pale yellow residue distilled in vacuo

出典と根拠

ORDレコード
ord-e537d7b8b53e40359f2afc800bf1e2f2
出典データセット
uspto-grants-1977_02
特許番号
US04007140

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