Acetyl chloride → 2-Propanone, 1-(4,5-dihydro-2-oxazolyl)-

HRID 435959

反応式

HRID 435959 の反応式
[CH3:1][C:2]1[O:3][CH2:4][CH2:5][N:6]=1.C([Li])CCC.[C:12](Cl)(=[O:14])[CH3:13]>O1CCCC1>[CH2:1]([C:2]1[O:3][CH2:4][CH2:5][N:6]=1)[C:12]([CH3:13])=[O:14]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 707132-Methyl-2-oxazolineHCID 178418339Butyllithium

生成物 1

HCID 836422-Propanone, 1-(4,5-dihydro-2-oxazolyl)-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 8.5 g. (0.1 mole) of 2-methyl-1,3-oxazoline in 85 ml. of dry tetrahydrofuran, and cooled in an acetone-dry ice bath to -60° C., is added 6.4 g. (0.1 mole) of n-butyl lithium and the reaction mixture allowed to stir for 1 hour. To the cloudy solution is then added 7.8 g. (0.1 mole) of acetyl chloride at such a rate that the temperature is maintained below -50° C. The reaction mixture is allowed to warm to room temperature and is then filtered and the solvent removed in vacuo. The desired product is purified by distillation under reduced pressure.

後処理

  1. additionis added 6.4 g
  2. additionTo the cloudy solution is then added 7.8 g
  3. filtrationis then filtered
  4. customthe solvent removed in vacuo
  5. distillationThe desired product is purified by distillation under reduced pressure

出典と根拠

ORDレコード
ord-620835d5b0114d35a634cbba05618c46
出典データセット
uspto-grants-1977_02
特許番号
US04007184

関連ノート

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