Morpholine → N-(1-adamantyl)morpholine-4-carbothioamide

HRID 436002

反応式

HRID 436002 の反応式
[C:1]12([N:11]=[C:12]=[S:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>CCOCC>[C:1]12([NH:11][C:12]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[S:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 2

HCID 8083MorpholineHCID 107279Adamantyl isothiocyanate

生成物 1

HCID 2828003N-(1-adamantyl)morpholine-4-carbothioamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The thiourea is prepared by reacting 5.0 g. (0.026 mole) of 1-adamantyl isothiocyanate with 2.5 g. (0.029 mole) of morpholine in 250 ml. of ether for ca. 1 hr. at room temperature. The solid which separates is collected and combined with additional compound from concentration of ether filtrate to a small volume: 6.65 g. (91 percent), m.p. 145-147. The analytical sample is recrystallized from ether, m.p. 148.

後処理

  1. customat room temperature
  2. customThe solid which separates is collected
  3. customThe analytical sample is recrystallized from ether

出典と根拠

ORDレコード
ord-6912602631aa45beb0219a09ad070591
出典データセット
uspto-grants-1977_02
特許番号
US04007181

関連ノート

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