Sodium Iodide → 3-Hydroxy-1-iodo-4-octyne

HRID 436088ノート

反応式

HRID 436088 の反応式
[I-:1].[Na+].Cl[CH2:4][CH2:5][CH:6]([OH:12])[C:7]#[C:8][CH2:9][CH2:10][CH3:11]>CC(=O)CC>[OH:12][CH:6]([C:7]#[C:8][CH2:9][CH2:10][CH3:11])[CH2:5][CH2:4][I:1]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 204655481-Chlorooct-4-yn-3-ol

生成物 1

HCID 204656213-Hydroxy-1-iodo-4-octyne

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒2 回

実験手順

A mixture of 15 g. of sodium iodide in 100 ml. of 2-butanone is stirred at the reflux temperature for 30 minutes. To the cooled mixture is added 12 g. of 1-chloro-3-hydroxy-4-octyne in 150 ml. of 2-butanone. The resulting mixture is stirred at the reflux temperature for 18 hours then cooled and filtered. The mother liquor is taken to dryness and the residue is triturated with benzene and filtered. The benzene is taken to dryness to give the subject product as an oil. The material is shown to be homogeneous by vapor phase chromatography and thin layer chromatography.

後処理

  1. additionA mixture of 15 g
  2. additionTo the cooled mixture is added 12 g
  3. temperaturethen cooled
  4. filtrationfiltered
  5. customthe residue is triturated with benzene
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-12eb0d0e7a464594bcb6448d6c05d57a
出典データセット
uspto-grants-1977_02
特許番号
US04007210

反応ノート

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