Sodium borohydride → 1-Bromo-trans-1-octen-3-ol

To an ice cooled mixture of 20 g. of sodium borohydride in 800 ml. of anhydrous ethanol is added 160 g. of crude 1-bromo-trans-1-octen-3-one (Example 992) over a period of 0.5 hour. The mixture is stirred for 2 hours with ice cooling and is then partitioned between ice water and benzene. The organic phase is washed with water and saturated brine, dried (Na2SO4), and evaporated to an oil. Distillation gives the product as an oil, b.p. 66°-68° C. (0.025 torr.).

1. additionmixture of 20 g
2. customis then partitioned between ice water and benzene
3. washThe organic phase is washed with water and saturated brine
4. dry with materialdried (Na2SO4)
5. customevaporated to an oil
6. distillationDistillation

ORDレコード

ord-f5b8bc9d00db43c78d66e9b70db3df59

出典データセット

uspto-grants-1977_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04007210