Dichloromethane → HCID 21455283、化合物

HRID 436198ノート

反応式

HRID 436198 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.C(Cl)Cl>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 21455293HCID 21455293、化合物

生成物 1

HCID 21455283HCID 21455283、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-(3-Benzyloxyphenyl)-5H-s-triazolo[5,1-a] isoindole (17 g) is suspended in 500 ml of ethanol and hydrogenated at atmospheric pressure and room temperature in the presence of 3 g of 10% Pd on charcoal. After addition of 500 ml of methylene chloride, the catalyst is filtered off and the solution is concentrated to dryness. The title product is purified by crystallization from dioxane. Yield 10.68 g (85.7%); m.p. 251-2°C.

後処理

  1. filtrationthe catalyst is filtered off
  2. concentrationthe solution is concentrated to dryness
  3. customThe title product is purified by crystallization from dioxane

出典と根拠

ORDレコード
ord-9a82c6f61a1e4f68bfca44da947ee874
出典データセット
uspto-grants-1977_02
特許番号
US04007276

反応ノート

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