Iodoethane → 2-(3-Ethoxyphenyl)-5h-[1,2,4]triazolo[5,1-a]isoindole

HRID 436199ノート

反応式

HRID 436199 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:19]=[C:11]3[C:12]4[C:17]([CH2:18][N:10]3[N:9]=2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:5]=[CH:6][CH:7]=1.[O-][CH2:21][CH3:22].[Na+].C(I)C>C(O)C>[CH2:21]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[N:19]=[C:11]3[C:12]4[C:17]([CH2:18][N:10]3[N:9]=2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:5]=[CH:6][CH:7]=1)[CH3:22]

参加物

5

反応物 3

HCID 6340Iodoethane2 回HCID 2723922Sodium ethoxideHCID 21455283HCID 21455283、化合物

生成物 1

HCID 1344512-(3-Ethoxyphenyl)-5h-[1,2,4]triazolo[5,1-a]isoindole収率 73%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

2-(3-Hydroxyphenyl)-5H-s-triazolo[5,1-a] isoindole (1.25 g, 0.05 mole) is added to 20 ml of ethanol containing one equivalent proportion of sodium ethoxide. To this mixture is added 0.49 ml (0.06 mole) of ethyl iodide in 5 ml of ethanol. After stirring for one hour at room temperature, a further amount of 0.49 ml of ethyl iodide is added. After refluxing for one hour the solvent is distilled off and the residue is washed with water and extracted with dichloromethane. Evaporation of the solvent and crystallization of the residue from ethanol gives 1 g (73%) of the title product, m.p. 166°-7° C.

後処理

  1. temperatureAfter refluxing for one hour the solvent
  2. distillationis distilled off
  3. washthe residue is washed with water
  4. extractionextracted with dichloromethane
  5. customEvaporation of the solvent and crystallization of the residue from ethanol

出典と根拠

ORDレコード
ord-410221a369704c02b3a1f49c9d41d587
出典データセット
uspto-grants-1977_02
特許番号
US04007276

反応ノート

読み込み中…