Ethylenediamine → 4-nitro-2-methyl-N-(beta-ureido-ethyl)aniline

HRID 436332

反応式

HRID 436332 の反応式
C(N)CN.ClC1C=CC([N+]([O-])=O)=CC=1C.Cl.[N+:17]([C:20]1[CH:29]=[CH:28][C:23]([NH:24][CH2:25][CH2:26][NH2:27])=[C:22]([CH3:30])[CH:21]=1)([O-:19])=[O:18].[N-:31]=[C:32]=[O:33].[K+]>>[N+:17]([C:20]1[CH:29]=[CH:28][C:23]([NH:24][CH2:25][CH2:26][NH:27][C:32]([NH2:31])=[O:33])=[C:22]([CH3:30])[CH:21]=1)([O-:19])=[O:18]

参加物

5

反応物 4

HCID 3301EthylenediamineHCID 83315Benzene, 1-chloro-2-methyl-4-nitro-HCID 11051572Potassio isocyanateHCID 17336835N-(2-methyl-4-nitrophenyl)ethane-1,2-diamine hydrochloride

生成物 1

HCID 214541964-nitro-2-methyl-N-(beta-ureido-ethyl)aniline

実験手順

4-nitro-2-methyl-N-(β-aminoethyl) aniline monohydrochloride is obtained by reacting ethylene diamine with 2-chloro-5-nitro-toluene. This monohydrochloride is then reacted with potassium isocyanate to produce 4-nitro-2-methyl-N-(β-ureidoethyl) aniline, which is reduced with hydrazine and Raney's nickel to 4-amino-2-methyl-N-(β-ureidoethyl) aniline.

出典と根拠

ORDレコード
ord-d9cb57c3fa2f41339e62a27c145c8718
出典データセット
uspto-grants-1977_02
特許番号
US04008272

関連ノート

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