関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 3,4-Dihydro-isoquinolin-1-ylamine | HCID 9793824 | — |
| 反応物 | 1-Ethoxy-3,4-dihydroisoquinoline | HCID 12349038 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Hydrazinyl-3,4-dihydroisoquinoline | HCID 12349041 | — |
反応手順
A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04009170 |
|---|
| 出典データセット | uspto-grants-1977_02 |
|---|
| ORD ID | ord-c56f3b2b50184e3084ea8ec85fc05f53 |
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| 出典メモ | uspto-grants-1977_02 |
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