反应详情

温度

25 °C

A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).

1. filtrationThe mixture was filtered
2. customAn ether solution of the crystals which separated from the filtrate
3. temperatureon chilling
4. washwas washed with water
5. customdried
6. filtrationfiltered
7. customConcentration of the filtrate and crystallization of the residue from ether