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Formaldehyde → 2-Phenyl-3-(3-morpholinopropionyl)benzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Morpholine, hydrochloride (1:1) | HCID 197884 | — |
| 反応物 | 1-(2-Phenylbenzofuran-3-yl)ethanone | HCID 13024726 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-Phenyl-3-(3-morpholinopropionyl)benzofuran | HCID 21452743 | — |
反応手順
A mixture of 23.6 grams of 2-phenyl-3- acetylbenzofuran, 70 milliliters of isopropanol, 4.2 grams of paraformaldehyde, and 17.3 grams of morpholine hydrochloride were heated under reflux at the boiling point for 12 hours, after which the solvent was evaporated therefrom under vacuum and the residue was triturated with dilute hydrochloric acid and the hydrochloride of the compound named in the heading of this example, which separated in the form of crystals therefrom, was separated from the mixture by suction filtration and dried. In this manner, 23.8 grams of the specified hydrochloride, which had a melting point of 177°-179°C, was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04009184 |
| 出典データセット | uspto-grants-1977_02 |
| ORD ID | ord-97fbee31cadf452da5ea122f3924efeb |
| 出典メモ | uspto-grants-1977_02 |