反应详情

A mixture of 23.6 grams of 2-phenyl-3- acetylbenzofuran, 70 milliliters of isopropanol, 4.2 grams of paraformaldehyde, and 17.3 grams of morpholine hydrochloride were heated under reflux at the boiling point for 12 hours, after which the solvent was evaporated therefrom under vacuum and the residue was triturated with dilute hydrochloric acid and the hydrochloride of the compound named in the heading of this example, which separated in the form of crystals therefrom, was separated from the mixture by suction filtration and dried. In this manner, 23.8 grams of the specified hydrochloride, which had a melting point of 177°-179°C, was obtained.

1. temperaturewere heated
2. temperatureunder reflux at the boiling point for 12 hours
3. customafter which the solvent was evaporated
4. customunder vacuum and the residue was triturated with dilute hydrochloric acid
5. customseparated in the form of crystals
6. customwas separated from the mixture by suction filtration
7. customdried
8. customwas obtained