Butyl cis(+/-)-2-(4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylate → Butyl cis(+/-)-2-(4-amino-3-ethoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylate
反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[O:19][C:20]([CH3:30])=[C:21]([C:23]([O:25][CH2:26][CH2:27][CH2:28][CH3:29])=[O:24])[N:22]=2)[CH2:14][C@H:13]1[O:31][CH2:32][CH3:33])=O)C1C=CC=CC=1>[Pd].CO>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[O:19][C:20]([CH3:30])=[C:21]([C:23]([O:25][CH2:26][CH2:27][CH2:28][CH3:29])=[O:24])[N:22]=2)[CH2:14][C@H:13]1[O:31][CH2:32][CH3:33]参加物
4
実験手順
The same operation as in Example (95b) was performed using butyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (112g) (1.05 g, 2.1 mmol), 10% Pd/C (0.25 g) and methanol (15 mL), to obtain 0.66 g of the title compound as a light brown oily substance (88%).
出典と根拠
- ORDレコード
- ord-7ddf58b99e7b49f3a2460b905233ad7d
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536197B2
反応ノート
読み込み中…